| City | Distance | Mileage |
|---|
| Distance from Valdivia to Santa Cruz | 599 km | 372 miles |
| Distance from Temuco to Santa Cruz | 469 km | 291 miles |
| Distance from Talca to Santa Cruz | 91 km | 57 miles |
| Distance from Santiago to Santa Cruz | 147 km | 91 miles |
| Distance from Santa Cruz to Rancagua | 77 km | 48 miles |
| Distance from Santa Cruz to Punta Arenas | 2,059 km | 1,279 miles |
| Distance from Santa Cruz to Puerto Montt | 772 km | 480 miles |
| Distance from Santa Cruz to La Serena | 527 km | 327 miles |
| Distance from Santa Cruz to Iquique | 1,608 km | 999 miles |
| Distance from Santa Cruz to Copiapo | 815 km | 506 miles |
| Distance from Santa Cruz to Concepcion | 287 km | 178 miles |
| Distance from Santa Cruz to Coihaique | 1,218 km | 757 miles |
| Distance from Santa Cruz to Arica | 1,800 km | 1,118 miles |
| Distance from Valparaiso to Santa Cruz | 179 km | 111 miles |
| Distance from Tarapaca to Santa Cruz | 1,618 km | 1,005 miles |
| Distance from Santiago Metropolitan to Santa Cruz | 149 km | 93 miles |
| Distance from Maule to Santa Cruz | 99 km | 62 miles |
| Distance from Los Lagos to Santa Cruz | 812 km | 505 miles |
| Distance from O'Higgins to Santa Cruz | 34 km | 21 miles |
| Distance from Coquimbo to Santa Cruz | 521 km | 324 miles |
| Distance from Biobio to Santa Cruz | 274 km | 170 miles |
| Distance from Atacama to Santa Cruz | 796 km | 495 miles |
| Distance from Araucania to Santa Cruz | 487 km | 303 miles |
| Distance from Antofagasta to Santa Cruz | 1,225 km | 761 miles |
| Distance from Aisen to Santa Cruz | 1,202 km | 747 miles |
| Distance from Magallanes to Santa Cruz | 1,954 km | 1,214 miles |
| Distance from Arica y Parinacota to Santa Cruz | 1,794 km | 1,115 miles |
| Distance from Los Rios to Santa Cruz | 628 km | 390 miles |
